Effectiveness of nano-hydroxyapatite toothpaste in reducing dentin hypersensitivity: A double-blind randomized controlled trial.

Michele Vano, DDS, PhD1/Giacomo Derchi, DDS, PhD, MSc2/Antonio Barone, DDS, PhD1/Ugo Covani, DMD3

Dentin hypersensitivity is a common dental clinical condition in permanent teeth and has been defined as acute pain for a short duration arising from the exposed dentin in response to thermal, evaporative, tactile, osmotic, or chemical stimuli, which cannot be  ascribed to any other form of dental defect or pathol- ogy by the presence of open dentinal tubules on an exposed dentinal surface.

Several theories have been used to explain the mechanisms of dentin hypersensitivity. The most widely accepted is the “hydrodynamic theory” proposed by Brännström in 1963.

According to this theory, open tubules of exposed dentin allow the movement of dentinal fluid within the dentinal tubules indirectly stimulating the pulp nerves. In support of this theory, individuals with dentin hypersensitivity show open dentinal tubules that are wider and more numerous than nonsensitive surfaces, which are mainly covered by a smear layer.

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